Respiratory chain and mitochondrial deoxyribonucleic acid in blood cells from patients with focal and generalized dystonia
Identifieur interne : 005B04 ( Main/Exploration ); précédent : 005B03; suivant : 005B05Respiratory chain and mitochondrial deoxyribonucleic acid in blood cells from patients with focal and generalized dystonia
Auteurs : Reichmann [Allemagne] ; Markus Naumann [Allemagne] ; Sabine Hauck [Allemagne] ; Bernd Janetzky [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 1994.
English descriptors
- KwdEn :
- Adult, Aged, Blood Platelets (metabolism), Blood cells, Blotting, Southern, Chromosome Deletion, DNA, Mitochondrial (blood), DNA, Mitochondrial (genetics), Dystonia, Dystonia (genetics), Dystonia (physiopathology), Electron Transport (genetics), Electron Transport (physiology), Female, Humans, Male, Middle Aged, Mitochondrial DNA, NAD(P)H Dehydrogenase (Quinone) (deficiency), Neurodegenerative disease, Neurologic Examination, Respiratory chain, Torticollis (genetics), Torticollis (physiopathology).
- MESH :
- chemical , blood : DNA, Mitochondrial.
- chemical , deficiency : NAD(P)H Dehydrogenase (Quinone).
- chemical , genetics : DNA, Mitochondrial.
- genetics : Dystonia, Electron Transport, Torticollis.
- metabolism : Blood Platelets.
- physiology : Electron Transport.
- physiopathology : Dystonia, Torticollis.
- Adult, Aged, Blotting, Southern, Chromosome Deletion, Female, Humans, Male, Middle Aged, Neurologic Examination.
Abstract
An increaseing number of neurodegenerative diseases seem to be associated with or even due to disturbancs of cerebral energy metabolism. One generally accepted example is complex I deficiency in substantia nigra from patients with Parkinson's disease. Reports on a complex I defect in platelets from patients with dystonia led us to check for disturbances of the respiratory chain or of the mitochondrial genome in isolated mitochondria from patients with focal or generalized dystonia. We could not confirm the idea of mitochondrial disturbance in platelets from patients with dystonia because we did not find abnormal enzyme activities or any deletions of the mitochondrial genome. Thus, we do not think that blood cells such as platelets can serve as markers for neurodegenerative disorders such as dystonia.
Url:
DOI: 10.1002/mds.870090603
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1994">1994</date><biblScope unit="vol">9</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="597">597</biblScope><biblScope unit="page" to="600">600</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">A7BBD25BD1689037BCA0CAF1FD7B188246E11ABA</idno><idno type="DOI">10.1002/mds.870090603</idno><idno type="ArticleID">MDS870090603</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Blood Platelets (metabolism)</term><term>Blood cells</term><term>Blotting, Southern</term><term>Chromosome Deletion</term><term>DNA, Mitochondrial (blood)</term><term>DNA, Mitochondrial (genetics)</term><term>Dystonia</term><term>Dystonia (genetics)</term><term>Dystonia (physiopathology)</term><term>Electron Transport (genetics)</term><term>Electron Transport (physiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mitochondrial DNA</term><term>NAD(P)H Dehydrogenase (Quinone) (deficiency)</term><term>Neurodegenerative disease</term><term>Neurologic Examination</term><term>Respiratory chain</term><term>Torticollis (genetics)</term><term>Torticollis (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>DNA, Mitochondrial</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>NAD(P)H Dehydrogenase (Quinone)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Mitochondrial</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dystonia</term><term>Electron Transport</term><term>Torticollis</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Blood Platelets</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Electron Transport</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dystonia</term><term>Torticollis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Blotting, Southern</term><term>Chromosome Deletion</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An increaseing number of neurodegenerative diseases seem to be associated with or even due to disturbancs of cerebral energy metabolism. One generally accepted example is complex I deficiency in substantia nigra from patients with Parkinson's disease. Reports on a complex I defect in platelets from patients with dystonia led us to check for disturbances of the respiratory chain or of the mitochondrial genome in isolated mitochondria from patients with focal or generalized dystonia. We could not confirm the idea of mitochondrial disturbance in platelets from patients with dystonia because we did not find abnormal enzyme activities or any deletions of the mitochondrial genome. Thus, we do not think that blood cells such as platelets can serve as markers for neurodegenerative disorders such as dystonia.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Basse-Franconie</li></region><settlement><li>Wurtzbourg</li></settlement></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Reichmann" sort="Reichmann" uniqKey="Reichmann" last="Reichmann">Reichmann</name></region><name sortKey="Hauck, Sabine" sort="Hauck, Sabine" uniqKey="Hauck S" first="Sabine" last="Hauck">Sabine Hauck</name><name sortKey="Janetzky, Bernd" sort="Janetzky, Bernd" uniqKey="Janetzky B" first="Bernd" last="Janetzky">Bernd Janetzky</name><name sortKey="Naumann, Markus" sort="Naumann, Markus" uniqKey="Naumann M" first="Markus" last="Naumann">Markus Naumann</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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